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Crank (2006)

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Synopsis: When the hit-man Chev Chelios is poisoned by the criminal Verona, his friend and doctor Miles advises him that he must keep his adrenaline levels elevated to stay alive. Chev meets his girlfriend Eve and together they look for Verona to kill him.
Directors: Mark Neveldine, Brian Taylor
Writers: Mark Neveldine, Brian Taylor
Stars: Jason Statham, Amy Smart, Carlos Sanz
Sources: IMDB, Wikipedia